Optimizing lipid-lowering therapy in coronary heart disease: Patterns of statin adherence

- Dolzhenko, Maryna (orcid.org/0000-0002-8559-9598) and Bilousova, Natalia (orcid.org/0000-0001-6732-426X) (2025) Optimizing lipid-lowering therapy in coronary heart disease: Patterns of statin adherence In: Selected Abstracts from Pharmacology 2025 . British Pharmacology Society, London, United Kingdom, p. 19. ISBN 0306-5251

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Abstract

A statistically significant association was found between gender and adherence to statin therapy: χ2(2)= 26.518, p < .001; Cramer's V= 0.428 (moderate effect size). Men demonstrated significantly higher adherence (84.3%) compared with women (66.6%). Significant associations were also observed between adherence and therapy intensity or dose adjustment: χ2(4)= 72.131, p < .001; likelihood ratio χ2(4)= 43.975, p < .001; linear-by-linear association test χ2(1)= 34.481, p < .001. The following measures confirmed statistically significant negative correlations between adherence and statin dose modifications: Somers' d (symmetrical)= 0.297, p= .005. Gamma= 0.579, p= .005. Spearman's rho= 0.313, p < .001. Pearson's r = .489, p < .001. φ coefficient= .705, p < .001, indicating a strong overall association. Higher adherence (MARS-5) was associated with fewer dose reductions or therapy changes, while lower adherence correlated with more modifi- cations. Men demonstrated significantly better adherence than women. Moderate-intensity statin therapy showed higher adherence than high- intensity regimens. Findings were supported by χ2, Cramer's V, Somers' d, gamma, Spearman's rho and Pearson's r analyses. A statistically significant, moderate association was found between gender and adherence to statin therapy in patients with CHD and comorbid- ities (χ2(2)= 26.518, p < .001; Cramer's V= 0.428, p < .001). Men demonstrated significantly higher adherence (84.3%) compared with women (66.6%). Patients at high cardiovascular risk showed better adherence when receiving moderate-intensity statin regimens, suggesting that dose optimization may enhance long-term persistence. Negative correlations between adherence and dose adjustments (gamma= 0.579; Spearman's rho= 0.313; Pearson's r = .489) confirm that unnecessary dose modifications may undermine adherence. Gender-sensitive strategies and patient-centred approaches, including education on cardiovascular risk and the long-term benefits of statin therapy, are needed to improve secondary prevention outcomes in CHD.

Item Type:	Book Section
Keywords:	Coronary Heart Disease, Statin Therapy, Adherence
Subjects:	Science and knowledge. Organization. Computer science. Information. Documentation. Librarianship. Institutions. Publications > 6 Applied Sciences. Medicine. Technology > 61 Medical sciences
Divisions:	Institute of Pedagogical Education and Education for the Adults > Common resources institute
Depositing User:	ИПТО НАПН Natalia Bilousova
Date Deposited:	08 Jan 2026 19:04
Last Modified:	08 Jan 2026 19:04
URI:	https://lib.iitta.gov.ua/id/eprint/748099

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