The impact of potential pharmacological drug interactions in the pharmacotherapy of ischemic heart disease with comorbid conditions on treatment adherence

- Білоусова, Наталя Анатоліївна (orcid.org/0000-0001-6732-426X) and Долженко, Марина Миколаївна (orcid.org/0000-0002-8559-9598) (2025) The impact of potential pharmacological drug interactions in the pharmacotherapy of ischemic heart disease with comorbid conditions on treatment adherence In: Збірник тез доповідей Всеукраїнської науково-практичної конференції з міжнародною участю «Запорізький фармацевтичний форум – 2025: Фармація майбутнього – від сучасного стану до глобальних викликів», м. Запоріжжя, 20-21 листопада 2025 р. . ЗДМФУ, м. Запоріжжя, Україна, pp. 11-12.

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Abstract

Ischemic heart disease (IHD) is associated with a high level of comorbidity, which necessitates the use of complex treatment regimens in pharmacotherapy. In such cases, multicomponent pharmacotherapy significantly increases the risk of pharmacological interactions, which may result in both enhanced therapeutic effects (synergism) and negative outcomes (antagonism, toxic effects). These drug interactions may influence the level of treatment adherence in patients with IHD and comorbid conditions. The assessment of the systemic impact of potential drug–drug interactions, classified according to the type of pharmacodynamic response (synergism, antagonism, toxicity), on adherence to pharmacotherapy in patients with IHD and comorbid conditions, followed by risk prediction associated with reduced adherence, reliably confirmed an increased risk of low treatment adherence. In particular, this was observed for potential drug interactions caused by pharmacodynamic antagonism (OR ≈ 1.74) and toxic effects resulting from potential drug–drug interactions (OR ≈ 1.36). The identified risks can be minimized through the implementation of a multidisciplinary approach to healthcare delivery and the involvement of clinical pharmacists in quality control of complex medication regimens, with subsequent optimization of pharmacotherapy for IHD in patients with comorbid conditions.

Item Type:	Book Section
Keywords:	Adherence to treatment, drug interactions, coronary heart disease, pharmaceutical care
Subjects:	Science and knowledge. Organization. Computer science. Information. Documentation. Librarianship. Institutions. Publications > 6 Applied Sciences. Medicine. Technology > 61 Medical sciences
Divisions:	Institute of Pedagogical Education and Education for the Adults > Common resources institute
Depositing User:	ИПТО НАПН Natalia Bilousova
Date Deposited:	19 Dec 2025 09:25
Last Modified:	19 Dec 2025 09:25
URI:	https://lib.iitta.gov.ua/id/eprint/747757

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