The impact of optimizing pharmacotherapy of coronary heart disease with comorbid conditions on adherence to treatment according to the EUROASPIRE V observational study in Ukraine

- Bilousova, Natalia (orcid.org/0000-0001-6732-426X) and Dolzhenko, Maryna (orcid.org/0000-0002-8559-9598) (2025) The impact of optimizing pharmacotherapy of coronary heart disease with comorbid conditions on adherence to treatment according to the EUROASPIRE V observational study in Ukraine In: FIP Pharmacy Practice Research summer meeting for PhD students, postdoctoral fellows and supervisors conference abstracts 2025 , 5 (25). International Pharmaceutical Federation, c. Hague, Netherlands, p. 4. ISBN 1477-2701

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Abstract

Pharmacotherapy for coronary heart disease (CHD) often involves the simultaneous use of three to ten drugs. It has been established that adherence to treatment significantly influences clinical outcomes. The results of the EUROASPIRE V observational study revealed a low level of treatment adherence among patients with CHD and comorbid conditions across European countries, highlighting the impact of socioeconomic, psychological, and other factors, particularly in Ukraine. This study analyzed medical records of CHD patients with comorbid conditions who participated in the EUROASPIRE V observational study in Ukraine. Data were collected over two visits to secondary care physicians across six regional centers in Ukraine. Statistical analysis included: Wilcoxon paired t-test for assessing prescription tablet distribution, adherence levels, and discrepancies between the two visits; Mann-Whitney test to compare adherence levels between adherent and non- adherent groups; Chi-square test (χ²) to determine the impact of medicines interactions on treatment adherence. Polypharmacy prevalence was 76.47% (CI 95%: 76.47 ± 0.03; p < 0.0001), reflecting the use of complex treatment regimens for CHD with comorbid conditions. The impact of drug interactions via CYP450 isoenzyme 3A4 was significantly associated with treatment adherence (χ² = 3.97; dof = 1; p = 0.0462). The findings highlight the need for fixed-dose drug combinations and improved coordination among healthcare providers to enhance adherence.

Item Type:	Book Section
Keywords:	Coronary heart disease, adherence to treatment, pharmacotherapy
Subjects:	Science and knowledge. Organization. Computer science. Information. Documentation. Librarianship. Institutions. Publications > 6 Applied Sciences. Medicine. Technology > 61 Medical sciences
Divisions:	Institute of Pedagogical Education and Education for the Adults > Common resources institute
Depositing User:	ИПТО НАПН Natalia Bilousova
Date Deposited:	08 Oct 2025 10:45
Last Modified:	08 Oct 2025 10:45
URI:	https://lib.iitta.gov.ua/id/eprint/746708

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