Nonclassical form of adrenogenital syndrome: features, diagnosis and treatment

- Ризничук, М.О. ( and Пішак, В.П. ( (2017) Nonclassical form of adrenogenital syndrome: features, diagnosis and treatment The Unity of science, 1 (10). pp. 118-120. ISSN 9091-1792


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Nonclassical form of adrenogenital syndrome (AGS) – one of the most frequent causes of hyperandrogenism in girls. The study involved six patients aged 15-17 years with nonclassical form of AGS who were registered at the Cher- nivtsi Regional Children‘s Hospital.All investigators had female karyotype (46 (XX)) and signs of hyperandrogenism and violation of ovarian-menstrual cycle. On examination of the external genitalia was found the I degree of virilization by Prader (50%). By ultrasound examination of the pelvis was revealed secondary scleropolicystosis of ovaries in 66% of cases. 17-hydroxyprogesterone, free testosterone, DEAS levels were increased in the blood. In all patients during received positive result of tests with dexamethasone. Treatment with dexamethasone was conducted from 1/8 to 1/2 once every night, sometimes every other day. In some cases along with dexamethasone were appointed antiandrogens (cyproterone acetate). Timely diagnosis of AGS in teenage girls allows to start the appropriate treatment in consideration of peculiarities of its flow, which reduces the manifestations of the disease and supports the stage of medicational compensation.

Item Type: Article
Keywords: adrenogenital syndrome, nonclassical form, girls, violation of ovarian-menstrual cycle, diagnosis
Subjects: Science and knowledge. Organization. Computer science. Information. Documentation. Librarianship. Institutions. Publications > 6 Applied Sciences. Medicine. Technology > 61 Medical sciences
Divisions: Institute of Psychology after N.Kostiuk > Common resources institute
Depositing User: чл.-кор. Василь Павлович Пішак
Date Deposited: 05 Nov 2018 20:57
Last Modified: 01 Feb 2019 01:18


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